SCHEMBL562070

SCHEMBL562070

COC(=O)CCON(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.49
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
TDP1 Q9NUW8 2/20 0.46
CA12 O43570 2/20 0.46
CA9 Q16790 2/20 0.46
CA7 P43166 1/20 0.46
CA14 Q9ULX7 1/20 0.46
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
LTA4H P09960 2/20 0.45
POLB P06746 1/20 0.42
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
AKT1 P31749 1/20 0.41
HTT P42858 1/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7086879 0.86 TDP1 (0.40) KDM4EALDH1A1LMNATDP1CA12
SCHEMBL2238587 0.84 ALOX5 (0.49) ALDH1A1LMNATDP1NPC1RAB9A
SCHEMBL7920783 0.83 KEAP1 (0.48) LMNATDP1CA12CA9NPC1
SCHEMBL561596 0.81 KEAP1 (0.47) LMNATDP1CA12CA9NPC1
SCHEMBL2241139 0.81 TDP1 (0.51) ALDH1A1LMNATDP1NPC1RAB9A
SCHEMBL10352510 0.80 TDP1 (0.46) ALDH1A1LMNATDP1CA12CA9
SCHEMBL9856644 0.79 NPC1 (0.43) ALDH1A1LMNANPC1RAB9AKMT2A
Potassium Ion SCHEMBL561597 0.79 HDAC3 (0.46) ALDH1A1LMNATDP1CA12CA9
SCHEMBL10351423 0.79 TSHR (0.48) KDM4EALDH1A1LMNATDP1NPC1
SCHEMBL3258895 0.77 TDP1 (0.54) KDM4EALDH1A1LMNATDP1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0240462-B1 SUBSTITUTED AMINOOXYPROPANOATE CIBA-GEIGY AG (CH) 1990-08-01 EP claimed
EP-0240462-A2 Substituted aminooxypropanoate CIBA-GEIGY AG (CH) 1987-10-07 EP claimed
EP-2880092-B1 PHOSPHITE COMPOSITIONS SI GROUP SWITZERLAND CHAA GMBH (CH) 2020-09-30 EP disclosed
EP-2459576-B1 LIQUID ALKYLATED TRISARYL PHOSPHITE COMPOSITIONS HAVING TWO ALKYL GROUPS WITH DIFFERENT CARBON NUMBER ADDIVANT SWITZERLAND GMBH (CH) 2018-11-21 EP disclosed
EP-2459575-B2 HYDROLYTICALLY STABLE PHOSPHITE COMPOSITIONS ADDIVANT SWITZERLAND GMBH (CH) 2018-07-25 EP disclosed
EP-2917276-B1 STABILIZED HIGH-DENSITY POLYETHYLENE COMPOSITION WITH IMPROVED RESISTANCE TO DETERIORATION AND STABILZER SYSTEM EQUISTAR CHEM LP (US) 2018-07-18 EP disclosed
EP-2459574-B1 SOLID ALKYLARYL PHOSPHITE COMPOSITIONS AND METHODS FOR MANUFACTURING SAME ADDIVANT SWITZERLAND GMBH (CH) 2018-06-20 EP disclosed
EP-1885787-B1 PHOSPHITE ADDITIVES IN POLYOLEFINS PHILLIPS PETROLEUM CO (US) 2018-01-10 EP disclosed
EP-2491078-B1 POLYMERS WITH LOW GEL CONTENT AND ENHANCED GAS-FADING ADDIVANT SWITZERLAND GMBH (CH) 2016-09-28 EP disclosed
EP-2917276-A1 STABILIZED HIGH-DENSITY POLYETHYLENE COMPOSITION WITH IMPROVED RESISTANCE TO DETERIORATION AND STABILZER SYSTEM Equistar Chemicals LP (US) 2015-09-16 EP disclosed
EP-2459578-B1 SOLID ALKYLARYL PHOSPHITE COMPOSITIONS AND METHODS FOR MANUFACTURING SAME ADDIVANT SWITZERLAND GMBH (CH) 2015-08-19 EP disclosed
US-5141975-A Melt processability, discoloration inhibition GENERAL ELECTRIC COMPANY (US) 1992-08-25 US disclosed
US-5137950-A Reacting phosphorous trichloride with alcohol; polymer stabilizer BORG-WARNER SPECIALTY CHEMICALS, INC. (US) 1992-08-11 US disclosed
US-5124472-A From tetrahydroabiethyl alcohol GENERAL ELECTRIC COMPANY (US) 1992-06-23 US disclosed
EP-0460461-A1 Hydrolytically stable phosphites GENERAL ELECTRIC COMPANY (US) 1991-12-11 EP disclosed
US-5023285-A Melt flow and color stabilizers for polymers G E SPECIALTY CHEMICALS (US) 1991-06-11 US disclosed
EP-0240462-B1 SUBSTITUTED AMINOOXYPROPANOATE CIBA-GEIGY AG (CH) 1990-08-01 EP disclosed
EP-0356687-A1 Bis (tri-tertiary-alkylphenoxy) diphosphaspiroundecanes GE SPECIALTY CHEMICALS, INC. (US) 1990-03-07 EP disclosed
EP-0356688-A2 3, 9-diphosphaspiroundecanes and process for making 3, 9-diphosphaspiroundecanes GE SPECIALTY CHEMICALS, INC. (US) 1990-03-07 EP disclosed
EP-0240462-A2 Substituted aminooxypropanoate CIBA-GEIGY AG (CH) 1987-10-07 EP disclosed