Incadronic Acid

Incadronic Acid

SCHEMBL223885

O=P(O)(O)C(NC1CCCCCC1)P(=O)(O)O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ANPEP P15144 2/20 0.48
ERAP2 Q6P179 2/20 0.48
MMP2 P08253 7/20 0.47
CA12 O43570 5/20 0.47
CA1 P00915 5/20 0.47
CA2 P00918 5/20 0.47
CA9 Q16790 5/20 0.47
MMP1 P03956 2/20 0.47
MMP8 P22894 2/20 0.47
MMP3 P08254 1/20 0.47
FDPS P14324 3/20 0.42
EPHX1 P07099 5/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
MAPT P10636 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP3A4 P08684 1/20 0.39
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(Cyclooctylamino)Methylenediphosphonic Acid SCHEMBL9777403 1.00 ANPEP (0.48) ANPEPERAP2MMP2CA12CA1
(Cyclohexylamino)Methylenediphosphonic Acid SCHEMBL8370913 1.00 ANPEP (0.48) ANPEPERAP2MMP2CA12CA1
(Cyclopentylamino)Methylenediphosphonic Acid SCHEMBL9626232 0.98 ANPEP (0.46) ANPEPERAP2MMP2CA12CA1
Incadronic Acid SCHEMBL2898450 0.96 ANPEP (0.46) ANPEPERAP2MMP2CA12CA1
(Cyclobutylamino)Methylenediphosphonic Acid SCHEMBL9626988 0.93 MMP2 (0.45) ANPEPERAP2MMP2CA12CA1
(Cyclopropylamino)Methylenediphosphonic Acid SCHEMBL9627717 0.88 MMP2 (0.41) ANPEPERAP2MMP2CA12CA1
Incadronic Acid SCHEMBL2898447 0.85 ANPEP (0.41) ANPEPERAP2MMP2CA12CA1
Incadronic Acid SCHEMBL29355743 0.81 MMP2 (0.42) ANPEPERAP2MMP2CA12CA1
SCHEMBL18657116 0.80 ANPEP (0.47) ANPEPERAP2MMP2CA12CA1
SCHEMBL10419330 0.78 HDAC3 (0.33) ANPEPERAP2MMP2MMP1MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3041 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12529035-B1 Method for producing induced pluripotent stem cells NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (JP) 2026-01-20 US claimed
US-20260000734-A1 METHODS FOR EXPANDING AND ACTIVATING yo T CELLS FOR THE TREATMENT OF CANCER AND RELATED MALIGNANCIES IMMATICS US INC (US) 2026-01-01 US claimed
WO-2025261951-A1 COMBINATION THERAPY WITH AN ANTI-CA19-9 ANTIBODY AND FOLFIRINOX IN THE TREATMENT OF CANCER BioNTech SE (DE) 2025-12-26 WO claimed
EP-3717634-B1 METHODS FOR ACTIVATING, MODIFYING AND EXPANDING GAMMA DELTA T CELLS FOR THE TREATMENT OF CANCER AND RELATED MALIGNANCIES IMMATICS US INC (US) 2025-10-15 EP claimed
US-12440541-B2 Methods for expanding and activating γσ T cells for the treatment of cancer and related malignancies Immatics US, Inc. (US) 2025-10-14 US claimed
EP-4602049-A1 SOS1 INHIBITORS Bayer Aktiengesellschaft (DE) 2025-08-20 EP claimed
EP-4587439-A1 SULFONE-SUBSTITUTED PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER Bayer Aktiengesellschaft (DE) 2025-07-23 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-20250154170-A1 FUSED PYRIMIDINES AS KRAS INHIBITORS BAYER AKTIENGESELLSCHAFT (DE) 2025-05-15 US claimed
WO-2025021997-A1 NEW MAP4K1 INHIBITORS Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2025-01-30 WO claimed
EP-0600834-A1 Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing CIBA-GEIGY AG (CH) 1994-06-08 EP claimed
WO-1994000129-A1 USE OF PHOSPHONATES FOR THE TREATMENT OF OSTEOPOROSIS PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) 1994-01-06 WO claimed
EP-0573604-A1 METHODS FOR THE TREATMENT OF OSTEOPOROSIS. NORWICH EATON PHARMA (US) 1993-12-15 EP claimed
EP-0550385-A1 Oral pharmaceutical compositions containing derivatives of methane-diphosphonic acid and 18-crown-6 ethers CIBA-GEIGY AG (CH) 1993-07-07 EP claimed
WO-1993011786-A1 METHODS FOR THE TREATMENT OF OSTEOPOROSIS USING BISPHOSPHONATES AND PARATHYROID HORMONE PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) 1993-06-24 WO claimed
WO-1992014474-A1 METHODS FOR THE TREATMENT OF OSTEOPOROSIS NORWICH EATON PHARMACEUTICALS, INC. (US) 1992-09-03 WO claimed
EP-0325482-B1 (CYCLOALKYLAMINO)METHYLENEBISPHOSPHONIC ACIDS AND MEDICINES CONTAINING THEM YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1992-04-01 EP claimed
US-5041428-A Bone resorption inhibitor, antiarthritic agent YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1991-08-20 US claimed
US-4970335-A ANTIARTHRITIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1990-11-13 US claimed
EP-0325482-A1 (Cycloalkylamino)methylenebisphosphonic acids and medicines containing them YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1989-07-26 EP claimed