Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 3/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 7/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Incadronic Acid SCHEMBL223885 | 0.98 | ANPEP (0.48) | ANPEPERAP2MMP2CA12CA1 | |
| (Cyclohexylamino)Methylenediphosphonic Acid SCHEMBL8370913 | 0.98 | ANPEP (0.48) | ANPEPERAP2MMP2CA12CA1 | |
| (Cyclooctylamino)Methylenediphosphonic Acid SCHEMBL9777403 | 0.98 | ANPEP (0.48) | ANPEPERAP2MMP2CA12CA1 | |
| (Cyclobutylamino)Methylenediphosphonic Acid SCHEMBL9626988 | 0.95 | MMP2 (0.45) | ANPEPERAP2MMP2CA12CA1 | |
| Incadronic Acid SCHEMBL2898450 | 0.94 | ANPEP (0.46) | ANPEPERAP2MMP2CA12CA1 | |
| (Cyclopropylamino)Methylenediphosphonic Acid SCHEMBL9627717 | 0.90 | MMP2 (0.41) | ANPEPERAP2MMP2CA12CA1 | |
| Incadronic Acid SCHEMBL2898447 | 0.82 | ANPEP (0.41) | ANPEPERAP2MMP2CA12CA1 | |
| SCHEMBL9627714 | 0.80 | MMP2 (0.39) | ANPEPERAP2MMP2CA12CA1 | |
| SCHEMBL9777781 | 0.80 | FDPS (0.41) | ANPEPERAP2MMP2MMP8FDPS | |
| SCHEMBL10419330 | 0.80 | HDAC3 (0.33) | ANPEPERAP2MMP2MMP1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325482-B1 | (CYCLOALKYLAMINO)METHYLENEBISPHOSPHONIC ACIDS AND MEDICINES CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1992-04-01 | — | — | EP | disclosed |
| US-5041428-A | Bone resorption inhibitor, antiarthritic agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| US-4970335-A | ANTIARTHRITIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-11-13 | — | — | US | disclosed |
| EP-0325482-A1 | (Cycloalkylamino)methylenebisphosphonic acids and medicines containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1989-07-26 | — | — | EP | disclosed |