(Cyclohexylamino)Methylenediphosphonic Acid

(Cyclohexylamino)Methylenediphosphonic Acid

SCHEMBL8370913

O=P(O)(O)C(NC1CCCCC1)P(=O)(O)O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ANPEP P15144 2/20 0.48
ERAP2 Q6P179 2/20 0.48
MMP2 P08253 7/20 0.47
CA12 O43570 5/20 0.47
CA1 P00915 5/20 0.47
CA2 P00918 5/20 0.47
CA9 Q16790 5/20 0.47
MMP1 P03956 2/20 0.47
MMP8 P22894 2/20 0.47
MMP3 P08254 1/20 0.47
FDPS P14324 3/20 0.42
EPHX1 P07099 5/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
MAPT P10636 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP3A4 P08684 1/20 0.39
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(Cyclooctylamino)Methylenediphosphonic Acid SCHEMBL9777403 1.00 ANPEP (0.48) ANPEPERAP2MMP2CA12CA1
Incadronic Acid SCHEMBL223885 1.00 ANPEP (0.48) ANPEPERAP2MMP2CA12CA1
(Cyclopentylamino)Methylenediphosphonic Acid SCHEMBL9626232 0.98 ANPEP (0.46) ANPEPERAP2MMP2CA12CA1
Incadronic Acid SCHEMBL2898450 0.96 ANPEP (0.46) ANPEPERAP2MMP2CA12CA1
(Cyclobutylamino)Methylenediphosphonic Acid SCHEMBL9626988 0.93 MMP2 (0.45) ANPEPERAP2MMP2CA12CA1
(Cyclopropylamino)Methylenediphosphonic Acid SCHEMBL9627717 0.88 MMP2 (0.41) ANPEPERAP2MMP2CA12CA1
Incadronic Acid SCHEMBL2898447 0.85 ANPEP (0.41) ANPEPERAP2MMP2CA12CA1
Incadronic Acid SCHEMBL29355743 0.81 MMP2 (0.42) ANPEPERAP2MMP2CA12CA1
SCHEMBL18657116 0.80 ANPEP (0.47) ANPEPERAP2MMP2CA12CA1
SCHEMBL10419330 0.78 HDAC3 (0.33) ANPEPERAP2MMP2MMP1MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023107893-A2 TREATMENT OF NEUORODEGENERATIVE DISEASES THROUGH THE INHIBITION OF ATAXIN-2 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2023-06-15 WO claimed
EP-0566535-B1 Compositions comprising methanediphosphonic acids and ion-exchangers NOVARTIS AG (CH) 1999-08-11 EP claimed
US-5344825-A Cationic divinylbenzene-styrene copolymer with exchangeable phosphonic acid methylaminomethyl groups and sodium salts CIBA-GEIGY CORP. (US) 1994-09-06 US claimed
EP-0566535-A1 Compositions comprising methanediphosphonic acids and ion-exchangers CIBA-GEIGY AG (CH) 1993-10-20 EP claimed
US-RE50880-E1 Anti-human OX40L antibodies and methods of treatment KYMAB LIMITED (GB) 2026-05-05 US disclosed
US-20250263492-A1 ANTIBODIES, USES & METHODS KYMAB LTD (GB) 2025-08-21 US disclosed
EP-4562053-A1 ANTI-KIT ANTIBODY FORMULATIONS AND METHODS Celldex Therapeutics, Inc. (US) 2025-06-04 EP disclosed
WO-2025106361-A1 HUMAN NECTIN-4 BINDERS MERCK SHARP & DOHME LLC (US) 2025-05-22 WO disclosed
CN-119948056-A Anti-KIT antibody formulations and methods 塞尔德克斯医疗公司 2025-05-06 CN disclosed
US-20250129159-A1 METHODS OF TREATING CANCER USING ANTIBODIES AND MOLECULES THAT IMMUNOSPECIFICALLY BIND TO BTN1A1 STCUBE & CO INC (KR) 2025-04-24 US disclosed
US-20250052758-A1 RECEPTOR FOR VISTA PIERRE FABRE MEDICAMENT (FR) 2025-02-13 US disclosed
US-12215151-B2 Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 STCUBE & CO., INC. (KR) 2025-02-04 US disclosed
EP-0566535-B1 Compositions comprising methanediphosphonic acids and ion-exchangers NOVARTIS AG (CH) 1999-08-11 EP disclosed
US-5344825-A Cationic divinylbenzene-styrene copolymer with exchangeable phosphonic acid methylaminomethyl groups and sodium salts CIBA-GEIGY CORP. (US) 1994-09-06 US disclosed
EP-0566535-A1 Compositions comprising methanediphosphonic acids and ion-exchangers CIBA-GEIGY AG (CH) 1993-10-20 EP disclosed
EP-0325482-B1 (CYCLOALKYLAMINO)METHYLENEBISPHOSPHONIC ACIDS AND MEDICINES CONTAINING THEM YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1992-04-01 EP disclosed
US-5041428-A Bone resorption inhibitor, antiarthritic agent YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1991-08-20 US disclosed
US-4970335-A ANTIARTHRITIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1990-11-13 US disclosed
US-3979385-A HEAVY METAL COMPLEXING AGENTS HENKEL & CIE G.M.B.H. (DT) 1976-09-07 US disclosed
US-3957160-A Process for the prevention of precipitations in water or aqueous solutions HENKEL & CIE G.M.B.H. (DT) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12215151-B2 Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 CD274, BTN3A1, PDCD1LG2 ANPEP 464/4885ERAP2 3665/4885MMP2 2506/4885
US-20250129159-A1 METHODS OF TREATING CANCER USING ANTIBODIES AND MOLECULES THAT IMMUNOSPECIFICALLY BIND TO BTN1A1 CD274, BTN3A1, PDCD1LG2 ANPEP 464/4885ERAP2 3665/4885MMP2 2506/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.