Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12873970 | 0.76 | ALDH1A1 (0.44) | MAPTALDH1A1USP2HPGDALOX15 | |
| SCHEMBL28778944 | 0.71 | MAPT (0.48) | MAPTALDH1A1HPGDALOX15NPSR1 | |
| SCHEMBL28132009 | 0.71 | FAAH (0.56) | MAPTALDH1A1USP2HPGDALOX15 | |
| SCHEMBL28173058 | 0.70 | ALDH1A1 (0.44) | MAPTALDH1A1USP2HPGDALOX15 | |
| SCHEMBL10626000 | 0.70 | ALDH1A1 (0.41) | MAPTALDH1A1USP2HPGDALOX15 | |
| SCHEMBL528021 | 0.70 | HTR1A (0.42) | KIT | |
| SCHEMBL5214187 | 0.70 | PLA2G1B (0.41) | MAPTALDH1A1USP2HPGDALOX15 | |
| SCHEMBL17501675 | 0.70 | ALDH1A1 (0.49) | MAPTALDH1A1USP2HPGDALOX15 | |
| SCHEMBL27953858 | 0.69 | SMN1; SMN2 (0.54) | ALDH1A1HSD17B10POLBSMN1; SMN2PLA2G2A | |
| SCHEMBL12095430 | 0.69 | PARP10 (0.47) | MAPTALDH1A1POLBMRGPRX4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704118-A1 | AMINOIMIDAZOPYRIDAZINES AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2020-09-09 | — | — | EP | disclosed |