Sugi Predict

Sugi Predict / Compounds / SCHEMBL22400352

SCHEMBL22400352

SCHEMBL22400352

COC(=O)c1cc(I)c(COC(C)=O)cc1C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CFTR P13569 6/20 0.52
▸ SOS1 Q07889 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ NOTUM Q6P988 3/20 0.36
▸ MAPT P10636 1/20 0.35
▸ CA12 O43570 2/20 0.35
▸ CA1 P00915 2/20 0.35
▸ CA2 P00918 2/20 0.35
▸ CA7 P43166 2/20 0.35
▸ CA9 Q16790 2/20 0.35
▸ CA14 Q9ULX7 2/20 0.35
▸ PDK2 Q15119 1/20 0.35
▸ PDK4 Q16654 1/20 0.35
▸ MRGPRX4 Q96LA9 2/20 0.33
▸ EGFR P00533 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ LDHA P00338 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26334537 0.85 CFTR (0.58) CFTRSOS1ALDH1A1NOTUMMAPT
SCHEMBL22400551 0.77 CFTR (0.34) CFTRALDH1A1HSD17B10NOTUMMAPT
SCHEMBL23754415 0.76 CFTR (0.61) CFTRSOS1NOTUMMAPTCA12
SCHEMBL22400474 0.76 CFTR (0.61) CFTRSOS1NOTUMMAPTCA12
SCHEMBL29528849 0.76 CFTR (0.61) CFTRSOS1NOTUMMAPTCA12
SCHEMBL2495129 0.76 CFTR (0.43) CFTRALDH1A1HSD17B10NOTUMMAPT
SCHEMBL15797511 0.75 CFTR (0.78) CFTRSOS1ALDH1A1HSD17B10NOTUM
SCHEMBL2425745 0.72 CFTR (0.68) CFTRSOS1ALDH1A1HSD17B10NOTUM
SCHEMBL2428349 0.71 CFTR (0.56) CFTRSOS1ALDH1A1NOTUMMAPT
SCHEMBL31758221 0.71 NOTUM (0.46) CFTRSOS1ALDH1A1HSD17B10NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250122226-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2025-04-17 — — US disclosed
US-12227528-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2025-02-18 — — US disclosed
CN-117624207-A Glucose-sensitive albumin binding derivatives 诺和诺德股份有限公司 2024-03-01 — — CN disclosed
CN-111315751-B Glucose-sensitive albumin binding derivatives 诺和诺德股份有限公司 2023-12-12 — — CN disclosed
US-20230331745-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2023-10-19 — — US disclosed
US-20230331745-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2023-10-19 — — US disclosed
US-11767332-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2023-09-26 — — US disclosed
US-11767332-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2023-09-26 — — US disclosed
EP-4227313-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES Novo Nordisk A/S (DK) 2023-08-16 — — EP disclosed
EP-3707145-B1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2023-06-21 — — EP disclosed
US-20220081451-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2022-03-17 — — US disclosed
EP-3946363-A2 GLUCOSE SENSITIVE INSULIN DERIVATIVES Novo Nordisk A/S (DK) 2022-02-09 — — EP disclosed
US-11186595-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2021-11-30 — — US disclosed
US-11186595-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2021-11-30 — — US disclosed
CN-113646329-A Glucose-sensitive insulin derivatives 诺和诺德股份有限公司 2021-11-12 — — CN disclosed
US-20200325160-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK A/S (DK) 2020-10-15 — — US disclosed
US-20200325160-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK A/S (DK) 2020-10-15 — — US disclosed
WO-2020201041-A2 GLUCOSE SENSITIVE INSULIN DERIVATIVES NOVO NORDISK A/S (DK) 2020-10-08 — — WO disclosed
EP-3707145-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES Novo Nordisk A/S (DK) 2020-09-16 — — EP disclosed
CN-111315751-A Glucose-sensitive albumin binding derivatives 诺沃挪第克公司 2020-06-19 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12227528-B2 Glucose-sensitive albumin-binding derivatives ALB, DBI, FABP4 CFTR 4515/4885SOS1 3742/4885ALDH1A1 1240/4885
US-20230331745-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, DBI, FABP4 CFTR 4515/4885SOS1 3742/4885ALDH1A1 1240/4885
US-11767332-B2 Glucose-sensitive albumin-binding derivatives ALB, DBI, FABP4 CFTR 4515/4885SOS1 3742/4885ALDH1A1 1240/4885
US-20220081451-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, DBI, FABP4 CFTR 4515/4885SOS1 3742/4885ALDH1A1 1240/4885
US-20250122226-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, DBI, FABP4 CFTR 4515/4885SOS1 3742/4885ALDH1A1 1240/4885
US-11186595-B2 Glucose-sensitive albumin-binding derivatives ALB, GPR119, MLX CFTR 4477/4885SOS1 4110/4885ALDH1A1 456/4885
US-20200325160-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, GPR119, MLX CFTR 4477/4885SOS1 4110/4885ALDH1A1 456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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