Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608726 | 0.76 | SIGMAR1 (0.57) | SIGMAR1HTTMAPTKDM4ECYP3A4 | |
| SCHEMBL155224 | 0.73 | CYP3A4 (0.57) | SIGMAR1TSHRHTTMAPTKDM4E | |
| SCHEMBL139932 | 0.73 | CYP3A4 (0.57) | SIGMAR1TSHRHTTMAPTKDM4E | |
| SCHEMBL22402644 | 0.73 | CYP3A4 (0.57) | SIGMAR1TSHRHTTMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL11843455 | 0.72 | CYP3A4 (0.59) | SIGMAR1TSHRHTTMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL11847094 | 0.72 | CYP3A4 (0.59) | SIGMAR1TSHRHTTMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL11847097 | 0.72 | CYP3A4 (0.59) | SIGMAR1TSHRHTTMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL11847105 | 0.72 | CYP3A4 (0.59) | SIGMAR1TSHRHTTMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL11843450 | 0.72 | CYP3A4 (0.59) | SIGMAR1TSHRHTTMAPTKDM4E | |
| SCHEMBL843570 | 0.70 | KMT2A (0.61) | TSHRHTTMAPTKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186606-B2 | Compositions and methods of modulating the immune response by activating alpha protein kinase 1 | SHANGHAI YAO YUAN BIOTECHNOLOGY CO., LTD. (CN) | 2021-11-30 | — | — | US | disclosed |
| US-20200283468-A1 | COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1 | LUMINEX INTERNATIONAL (CN) | 2020-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11186606-B2 | Compositions and methods of modulating the immune response by activating alpha protein kinase 1 | PHKA1, PHKA2, PRKCA | SIGMAR1 3788/4885TSHR 2816/4885HTT 4845/4885 |
| US-20200283468-A1 | COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1 | PHKA1, PHKA2, PRKCA | SIGMAR1 3788/4885TSHR 2816/4885HTT 4845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.