SCHEMBL22420232

SCHEMBL22420232

CNC(=O)O[C@@H](CO)COC(=O)C#N

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 7/20 0.40
PRKCE Q02156 1/20 0.36
PRKCQ Q04759 1/20 0.36
PRKCD Q05655 1/20 0.36
CHRNB2 P17787 1/20 0.33
CHRNA4 P43681 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19968518 0.83 PRKCA (0.47) PRKCAPRKCEPRKCQPRKCDCHRNB2
SCHEMBL22420222 0.83 PRKCA (0.43) PRKCAPRKCEPRKCQPRKCD
SCHEMBL21098352 0.77 PRKCA (0.40) PRKCAPRKCEPRKCQPRKCDCHRNB2
SCHEMBL12199642 0.76 MAPK1 (0.41) PRKCAPRKCEPRKCQPRKCDCHRNB2
SCHEMBL12780598 0.73 CHRNB2 (0.42) PRKCACHRNB2CHRNA4
SCHEMBL19435389 0.71 CTSK (0.39) PRKCAPRKCEPRKCQPRKCDCHRNB2
SCHEMBL9671738 0.69 PRKCA (0.50) PRKCAPRKCEPRKCQPRKCD
SCHEMBL18650144 0.68 CYP1A2 (0.42) CHRNB2CHRNA4
SCHEMBL25967321 0.67 LMNA (0.42)
SCHEMBL9575888 0.67 EPHX1 (0.53) PRKCAPRKCEPRKCQPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10774099-B2 Phospholipidation of imidazoquinolines and oxoadenines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2020-09-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10774099-B2 Phospholipidation of imidazoquinolines and oxoadenines TLR7, TLR8, TLR9 PRKCA 1732/4885PRKCE 2031/4885PRKCQ 968/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.