Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13243994 | 0.80 | SIRT6 (0.63) | NPC1POLBRAB9AACHESIRT6 | |
| SCHEMBL6656697 | 0.78 | PPARG (0.61) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL14095309 | 0.77 | SIGMAR1 (0.57) | NPC1RAB9AGAAHTR1A | |
| SCHEMBL477320 | 0.74 | CNR2 (0.58) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL25688701 | 0.74 | PPARG (0.57) | NPC1RAB9AACHELMNAGAA | |
| SCHEMBL23441685 | 0.73 | MAPT (0.57) | NPC1RAB9ASIRT6LMNAGAA | |
| SCHEMBL1599288 | 0.73 | FYN (0.57) | NPC1POLBRAB9ASIRT6LMNA | |
| SCHEMBL24050778 | 0.72 | PPARG (0.51) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL27778631 | 0.72 | SIRT6 (0.51) | NPC1POLBRAB9AACHESIRT6 | |
| SCHEMBL20354340 | 0.72 | ALDH1A1 (0.55) | NPC1RAB9ASIRT6LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10772858-B2 | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10772858-B2 | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors | HIF1A, HIF1AN, EGLN2 | NPC1 3679/4885POLB 3148/4885RAB9A 3339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.