Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16694505 | 0.86 | HIF1A (0.55) | HIF1AEPAS1EP300HSP90AA1 | |
| SCHEMBL6656697 | 0.74 | PPARG (0.61) | ACHEPPARGPPARDPPARACA12 | |
| SCHEMBL10071255 | 0.72 | PDE4D (0.53) | HIF1APDE4DPTPN1EPAS1KDM4E | |
| SCHEMBL22420346 | 0.72 | HTT (0.41) | HIF1APDE4DACHEPPARGPPARD | |
| SCHEMBL22420260 | 0.71 | HIF1A (0.50) | HIF1AEPAS1ACHEEP300HSP90AA1 | |
| SCHEMBL31239009 | 0.69 | LMNA (0.46) | PDE4DPTPN1KDM4ECASP1CASP7 | |
| SCHEMBL5476809 | 0.69 | LMNA (0.46) | PDE4DPTPN1KDM4ECASP1CASP7 | |
| SCHEMBL22420303 | 0.69 | HIF1A (0.46) | HIF1AEPAS1 | |
| SCHEMBL6795851 | 0.68 | ODC1 (0.46) | PDE4DPTPN1KDM4ECASP1CASP7 | |
| SCHEMBL16694230 | 0.68 | HIF1A (0.67) | HIF1AEPAS1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10772858-B2 | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10772858-B2 | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors | HIF1A, HIF1AN, EGLN2 | HIF1A 1/4885PDE4D 1272/4885PTPN1 4019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.