Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20939184 | 0.78 | MAP3K14 (0.33) | MAP3K14 | |
| SCHEMBL23005491 | 0.78 | MAP3K14 (0.33) | MAP3K14 | |
| SCHEMBL20939543 | 0.77 | MAP3K14 (0.33) | MAP3K14 | |
| SCHEMBL22421149 | 0.75 | MAP3K14 (0.39) | MAP3K14 | |
| SCHEMBL20939798 | 0.69 | MAP3K14 (0.34) | MAP3K14 | |
| SCHEMBL20828220 | 0.66 | ALOX5 (0.41) | MAP3K14POLBGAAALOX5ALOX5AP | |
| SCHEMBL22421148 | 0.65 | ALDH1A1 (0.33) | MAP3K14 | |
| SCHEMBL18215107 | 0.65 | ALOX5 (0.40) | MAP3K14POLBGAAALOX5ALOX5AP | |
| SCHEMBL23005401 | 0.64 | MAP3K14 (0.31) | MAP3K14 | |
| SCHEMBL22017463 | 0.64 | ALDH1A1 (0.37) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478673-B1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-16 | — | — | EP | disclosed |