Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | CCR3 | P51677 | 1/20 | 0.58 |
| ▸ | MC4R | P32245 | 1/20 | 0.56 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13958988 | 0.81 | SIGMAR1 (0.79) | ADRA1DADRA1AADRA1BCCR3MBTD1 | |
| SCHEMBL13006766 | 0.80 | HRH3 (0.65) | MBTD1L3MBTL3L3MBTL1SIGMAR1SLC6A3 | |
| SCHEMBL3338493 | 0.80 | LMNA (0.62) | MC4RLMNAHRH3 | |
| SCHEMBL3240628 | 0.80 | CCR3 (0.63) | ADRA1DADRA1AADRA1BCCR3MC4R | |
| SCHEMBL15242106 | 0.79 | HRH3 (0.65) | MBTD1L3MBTL3L3MBTL1SIGMAR1SLC6A3 | |
| SCHEMBL6298869 | 0.78 | KMT2A (0.74) | LMNA | |
| SCHEMBL14407778 | 0.78 | SLC6A3 (0.83) | CCR3SIGMAR1SLC6A3HTR1ADRD2 | |
| SCHEMBL6056974 | 0.78 | SLC6A3 (0.83) | CCR3SIGMAR1SLC6A3HTR1ADRD2 | |
| SCHEMBL13150782 | 0.78 | SLC6A3 (0.83) | CCR3SIGMAR1SLC6A3HTR1ADRD2 | |
| SCHEMBL7264546 | 0.78 | SLC6A3 (0.83) | CCR3SIGMAR1SLC6A3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3708169-A1 | 2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | Agios Pharmaceuticals, Inc. (US) | 2020-09-16 | — | — | EP | disclosed |