Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.35 |
| ▸ | SCN1A | P35498 | 3/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.32 |
| ▸ | HRH1 | P35367 | 4/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18811782 | 0.85 | ESR1 (0.37) | CYP1A2CYP3A4SLC6A2SLC6A4CHRM2 | |
| SCHEMBL21085218 | 0.81 | ALDH1A1 (0.33) | CYP1A2SLC6A2SLC6A4SLC6A3ESR1 | |
| SCHEMBL23661902 | 0.79 | CYP11B1 (0.44) | CYP1A2CYP3A4ESR1ESR2TSHR | |
| SCHEMBL18427303 | 0.79 | KCNA5 (0.39) | CYP1A2CYP3A4SLC6A2SLC6A4CHRM2 | |
| SCHEMBL18598771 | 0.78 | KCNH2 (0.37) | CYP1A2CYP3A4SLC6A2SLC6A4CHRM2 | |
| SCHEMBL20667407 | 0.77 | NR3C2 (0.38) | ESR1ESR2NR3C2KCNH2 | |
| SCHEMBL20694212 | 0.76 | KCNA5 (0.40) | CYP1A2CYP3A4SLC6A2SLC6A4CHRM2 | |
| SCHEMBL18659830 | 0.76 | KCNA5 (0.40) | CYP1A2CYP3A4SLC6A2SLC6A4CHRM2 | |
| SCHEMBL21012176 | 0.75 | CYP1A2 (0.39) | CYP1A2CYP3A4ESR1ESR2TSHR | |
| SCHEMBL20115746 | 0.75 | PCSK9 (0.37) | CYP1A2CYP3A4SLC6A2SLC6A4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11345708-B2 | Substituted imidazo[1,2-a]imidazoles as modulators of metabotropic glutamate receptor 4 activity | HOFFMANN-LA ROCHE INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-20200291033-A1 | IMIDAZO[1,2-A]IMIDAZOL-2-ONE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS PARKINSON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11345708-B2 | Substituted imidazo[1,2-a]imidazoles as modulators of metabotropic glutamate receptor 4 activity | GRM2, GRM1, GRM3 | CYP1A2 3049/4885CYP3A4 2488/4885SLC6A2 220/4885 |
| US-20200291033-A1 | IMIDAZO[1,2-A]IMIDAZOL-2-ONE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS PARKINSON'S DISEASE | HTR2C, MC2R, GRIN2C | CYP1A2 1052/4885CYP3A4 2157/4885SLC6A2 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.