Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434605 | 1.00 | PDE10A (0.47) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL20887743 | 0.93 | KIF18A (0.43) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL31142600 | 0.92 | GPR119 (0.47) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL26100075 | 0.89 | PDE10A (0.46) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL16544566 | 0.89 | NOTUM (0.48) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL2171923 | 0.89 | PDE10A (0.46) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL803327 | 0.86 | KDM4D (0.53) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL22957556 | 0.84 | PDE10A (0.43) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL3270354 | 0.83 | MCHR1 (0.45) | PDE10AAAK1HSD11B1KDM4DGPR119 | |
| SCHEMBL1393433 | 0.83 | HSD11B1 (0.45) | PDE10AAAK1HSD11B1GPR119MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200291020-A1 | NEW [1,6]NAPHTHYRIDINE COMPOUNDS AND DERIVATIVES AS CDK8/CDK19 INHIBITORS | BOEHRINGER INGELHEIM RCV GMBH & CO. KG (AT) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291020-A1 | NEW [1,6]NAPHTHYRIDINE COMPOUNDS AND DERIVATIVES AS CDK8/CDK19 INHIBITORS | CDK9, CDK19, CDK8 | PDE10A 2706/4885AAK1 1821/4885HSD11B1 2964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.