Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
| ▸ | BLK | P51451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584552 | 0.93 | PRMT5 (0.38) | PRMT5WDR77DOT1LDNMT1DNMT3B | |
| SCHEMBL22434971 | 0.90 | SIRT2 (0.41) | PRMT5WDR77DOT1LDNMT1DNMT3B | |
| SCHEMBL23584659 | 0.85 | MEN1 (0.38) | PRMT5WDR77DNMT1DNMT3BMETTL3 | |
| SCHEMBL22435002 | 0.84 | PRMT5 (0.38) | PRMT5WDR77DOT1LSIRT2SIRT1 | |
| SCHEMBL23584729 | 0.84 | PRMT5 (0.38) | PRMT5WDR77DOT1LDNMT1DNMT3B | |
| SCHEMBL19343841 | 0.83 | PRMT5 (0.39) | PRMT5WDR77DOT1LDNMT1DNMT3B | |
| SCHEMBL23584612 | 0.82 | MAP4K4 (0.47) | PRMT5WDR77METTL3JAK2JAK1 | |
| SCHEMBL23584845 | 0.82 | ADK (0.41) | PRMT5WDR77DNMT1DNMT3BMETTL3 | |
| SCHEMBL22435081 | 0.80 | PRMT5 (0.36) | PRMT5WDR77DOT1LDNMT1DNMT3B | |
| SCHEMBL23584814 | 0.80 | ADK (0.44) | PRMT5WDR77DNMT1DNMT3BMETTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200289539-A1 | NOVEL SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200289539-A1 | NOVEL SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | PRMT5 1/4885WDR77 133/4885DOT1L 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.