Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584729 | 0.88 | PRMT5 (0.38) | MAP4K4PRMT5WDR77JAK2JAK1 | |
| SCHEMBL23584552 | 0.83 | PRMT5 (0.38) | MAP4K4PRMT5WDR77PTK6SRC | |
| SCHEMBL22434971 | 0.83 | SIRT2 (0.41) | PRMT5WDR77JAK2JAK1PTK6 | |
| SCHEMBL19344003 | 0.82 | MAP4K4 (0.43) | MAP4K4PRMT5WDR77METTL3 | |
| SCHEMBL22435004 | 0.82 | PRMT5 (0.37) | PRMT5WDR77JAK2JAK1PTK6 | |
| SCHEMBL22435002 | 0.80 | PRMT5 (0.38) | MAP4K4PRMT5WDR77METTL3 | |
| SCHEMBL23584841 | 0.79 | MEN1 (0.42) | PRMT5WDR77METTL3 | |
| SCHEMBL23584475 | 0.79 | PRMT5 (0.40) | PRMT5WDR77ABL1SRCMETTL3 | |
| SCHEMBL23584745 | 0.79 | PRMT5 (0.40) | PRMT5WDR77ABL1SRCMETTL3 | |
| SCHEMBL23584567 | 0.79 | DRD2 (0.38) | PRMT5JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |