Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.35 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584567 | 0.91 | DRD2 (0.38) | PRMT5DRD2JAK2JAK1IRAK1 | |
| SCHEMBL23584552 | 0.88 | PRMT5 (0.38) | PRMT5WDR77MAP4K4METTL3MEN1 | |
| SCHEMBL22434971 | 0.88 | SIRT2 (0.41) | PRMT5WDR77JAK2JAK1METTL3 | |
| SCHEMBL23584612 | 0.88 | MAP4K4 (0.47) | PRMT5WDR77MAP4K4JAK2JAK1 | |
| SCHEMBL22434914 | 0.86 | PRMT5 (0.37) | PRMT5WDR77DRD2MAP4K4JAK2 | |
| SCHEMBL23584451 | 0.86 | JAK2 (0.40) | DRD2JAK2JAK1CCRL2DDR1 | |
| SCHEMBL23584682 | 0.85 | JAK2 (0.39) | PRMT5WDR77DRD2JAK2JAK1 | |
| SCHEMBL22435004 | 0.84 | PRMT5 (0.37) | PRMT5WDR77JAK2JAK1METTL3 | |
| SCHEMBL19343894 | 0.83 | PRMT5 (0.41) | PRMT5WDR77METTL3DNMT1DNMT3B | |
| SCHEMBL22435002 | 0.82 | PRMT5 (0.38) | PRMT5WDR77MAP4K4METTL3DOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |