Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.53 |
| ▸ | TTR | P02766 | 2/20 | 0.53 |
| ▸ | G6PD | P11413 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12355310 | 1.00 | PTGS1 (0.53) | PTGS1PTGS2ALOX5TTRG6PD | |
| SCHEMBL11405206 | 0.86 | G6PD (0.53) | PTGS1PTGS2ALOX5TTRG6PD | |
| SCHEMBL11411182 | 0.82 | G6PD (0.53) | PTGS1PTGS2ALOX5TTRG6PD | |
| SCHEMBL11410190 | 0.81 | G6PD (0.56) | G6PDALDH1A1MAPTALOX15TSHR | |
| SCHEMBL11404389 | 0.80 | G6PD (0.55) | G6PDALDH1A1MAPTALOX15TSHR | |
| SCHEMBL11414206 | 0.80 | G6PD (0.51) | PTGS1PTGS2ALOX5TTRG6PD | |
| SCHEMBL11406439 | 0.77 | G6PD (0.60) | G6PDALDH1A1MAPTALOX15TSHR | |
| SCHEMBL11404342 | 0.77 | G6PD (0.56) | G6PDALDH1A1MAPTALOX15TSHR | |
| SCHEMBL264277 | 0.75 | ALDH1A1 (0.73) | G6PDALDH1A1MAPTALOX15TSHR | |
| SCHEMBL12349218 | 0.75 | ALDH1A1 (0.73) | G6PDALDH1A1MAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265620-B1 | SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2014-06-18 | — | — | EP | disclosed |
| US-8609858-B2 | Spiro derivatives of parthenin as novel anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-12-17 | — | — | US | disclosed |
| US-20110201661-A1 | Spiro Derivatives of Parthenin as Novel Anticancer Agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-08-18 | — | — | US | disclosed |
| EP-2265620-A1 | SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS | Council Of Scientific & Industrial Research (IN) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009110007-A1 | SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS | COUNCIL QF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201661-A1 | Spiro Derivatives of Parthenin as Novel Anticancer Agents | CDK10, NEK10, AKR1B10 | PTGS1 1873/4885PTGS2 2342/4885ALOX5 891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.