SCHEMBL22439740

SCHEMBL22439740

O=C(O)C(=O)c1ccc(Oc2cccc(Cl)c2)cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.50
XDH P47989 1/20 0.46
SLC22A12 Q96S37 1/20 0.46
FFAR1 O14842 1/20 0.44
LMNA P02545 1/20 0.44
MRGPRX4 Q96LA9 1/20 0.43
LPAR1 Q92633 1/20 0.43
LPAR5 Q9H1C0 1/20 0.43
KDM4E B2RXH2 2/20 0.43
ABL1 P00519 1/20 0.43
STK39 Q9UEW8 1/20 0.42
NAAA Q02083 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TSHR P16473 1/20 0.42
CASP1 P29466 1/20 0.42
FNTA P49354 1/20 0.42
FNTB P49356 1/20 0.42
NPC1 O15118 1/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29377336 0.86 TSHR (0.46) KMOXDHSLC22A12STK39SMN1; SMN2
SCHEMBL22406867 0.86 TSHR (0.46) KMOXDHSLC22A12STK39SMN1; SMN2
SCHEMBL22406919 0.84 KMO (0.43) KMOXDHSLC22A12LMNAABL1
SCHEMBL22439711 0.84 KMO (0.55) KMOFFAR1LMNAMRGPRX4KDM4E
SCHEMBL22406846 0.83 MAOB (0.50) KMOXDHSLC22A12LMNAMRGPRX4
SCHEMBL22439737 0.82 PARG (0.47) KMOLMNAKDM4ESTK39NPC1
SCHEMBL22439712 0.82 SCN9A (0.44) KMOSTK39SMN1; SMN2TSHRCASP1
SCHEMBL19898150 0.81 MAPT (0.49) KMOXDHSLC22A12LMNAABL1
SCHEMBL22439730 0.80 PPARA (0.45) KMOXDH
SCHEMBL28634624 0.80 POLB (0.58) KMOXDHSLC22A12LMNAMRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3712135-A1 AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGENT FOR AGRICULTURAL AND HORTICULTURAL USE, AND MATERIAL PROTECTION AGENT FOR INDUSTRIAL USE Kureha Corporation (JP) 2020-09-23 EP disclosed