SCHEMBL22440666

SCHEMBL22440666

O=C(NNC(=O)c1ncc(C(F)(F)F)cc1Br)NC1N=C(c2ccccc2)c2ccccc2NC1=O

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CCKBR P32239 17/20 0.61
▸ CCKAR P32238 11/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20474811 0.85 CCKBR (0.55) CCKBRCCKAR
SCHEMBL20474812 0.85 CCKBR (0.55) CCKBRCCKAR
SCHEMBL22440664 0.80 CCKBR (0.49) CCKBRCCKAR
SCHEMBL18395705 0.77 CBLB (0.54) CCKBRCCKAR
SCHEMBL18395706 0.77 CBLB (0.54) CCKBRCCKAR
SCHEMBL22222928 0.76 CCKBR (0.83) CCKBRCCKAR
SCHEMBL642151 0.76 CCKBR (0.76) CCKBRCCKAR
SCHEMBL644300 0.76 CCKBR (0.75) CCKBRCCKAR
SCHEMBL22440657 0.75 CCKBR (0.43) CCKBRCCKAR
SCHEMBL22440656 0.75 CCKBR (0.43) CCKBRCCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360117-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2024-10-31 — — US disclosed
US-11912695-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-02-27 — — US disclosed
US-11912695-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-02-27 — — US disclosed
US-11912695-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-02-27 — — US disclosed
US-20220227746-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2022-07-21 — — US disclosed
US-11254664-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2022-02-22 — — US disclosed
US-11254664-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2022-02-22 — — US disclosed
EP-3941525-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS Enanta Pharmaceuticals, Inc. (US) 2022-01-26 — — EP disclosed
US-20200299286-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2020-09-24 — — US disclosed
US-20200299286-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2020-09-24 — — US disclosed
WO-2020190935-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2020-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11254664-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 CCKBR 509/4885CCKAR 989/4885
US-11912695-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 CCKBR 509/4885CCKAR 989/4885
US-20240360117-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 CCKBR 509/4885CCKAR 989/4885
US-20220227746-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 CCKBR 509/4885CCKAR 989/4885
US-20200299286-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 CCKBR 509/4885CCKAR 989/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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