Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | GALK1 | P51570 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | PLEC | Q15149 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PYGM | P11217 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22441920 | 0.94 | POLB (0.60) | POLBHPSEXDHMAPK1GFER | |
| SCHEMBL7765911 | 0.93 | XDH (0.55) | POLBXDHKDM4ETDP1CYP2C9 | |
| SCHEMBL11576384 | 0.93 | POLB (0.54) | POLBHPSEMAPK1GFERKDM4E | |
| SCHEMBL8008958 | 0.90 | POLB (0.55) | POLBHPSEKDM4ETDP1CYP2C9 | |
| SCHEMBL11574967 | 0.90 | POLB (0.55) | POLBHPSEKDM4ETDP1CYP2C9 | |
| SCHEMBL8541373 | 0.88 | POLB (0.57) | POLBHPSEKDM4ETDP1CYP2C9 | |
| SCHEMBL27657682 | 0.88 | HPSE (0.51) | POLBHPSEXDHMAPK1GFER | |
| SCHEMBL8008956 | 0.86 | POLB (0.54) | POLBHPSEXDHKDM4ETDP1 | |
| SCHEMBL522949 | 0.86 | POLB (0.77) | POLBHPSEMAPK1GFERKDM4E | |
| SCHEMBL30287662 | 0.86 | POLB (0.77) | POLBHPSEMAPK1GFERKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717456-A1 | PROCESS FOR THE PREPARATION OF ROXADUSTAT AND ITS INTERMEDIATES | Dr. Reddy's Laboratories Limited (IN) | 2020-10-07 | — | — | EP | disclosed |
| US-20200299242-A1 | PROCESS FOR THE PREPARATION OF ROXADUSTAT AND ITS INTERMEDIATES | DR. REDDY'S LABORATORIES LIMITED (IN) | 2020-09-24 | — | — | US | disclosed |
| CN-111566090-A | Preparation method of roxasistat and intermediate thereof | 雷迪博士实验室有限公司 | 2020-08-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299242-A1 | PROCESS FOR THE PREPARATION OF ROXADUSTAT AND ITS INTERMEDIATES | CYP3A7, CYP3A4, CYP3A5 | POLB 786/4885HPSE 1643/4885XDH 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.