SCHEMBL22444732

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL31754334	1.00	HCAR2 (0.41)	HCAR2CYP11B1CYP11B2CYP2C9NAMPT
	SCHEMBL26008462	0.83	CTSB (0.49)	HCAR2CYP11B1CYP11B2CYP2C9NAMPT
	SCHEMBL13391884	0.82	ACE (0.40)	PPARGACEALDH1A1
	SCHEMBL21838030	0.82	PPARA (0.39)	HCAR2CYP11B1CYP11B2CYP2C9NAMPT
	SCHEMBL21838033	0.82	PPARA (0.39)	HCAR2CYP11B1CYP11B2CYP2C9NAMPT
	SCHEMBL25361477	0.82	HCAR2 (0.41)	HCAR2ACEGPR132CTSBITGB1
	SCHEMBL22444676	0.82	CASP3 (0.48)	HCAR2ALDH1A1ITGA4
	SCHEMBL22444674	0.82	HCAR2 (0.41)	HCAR2ACEGPR132CTSBITGB1
	SCHEMBL25358945	0.81	CYP11B1 (0.43)	CYP11B1CYP11B2ACEGPR132ITGB1
	SCHEMBL25358943	0.81	CYP11B1 (0.43)	CYP11B1CYP11B2ACEGPR132ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.