Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.68 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | ELANE | P08246 | 1/20 | 0.64 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2290505 | 0.88 | KDM4E (0.67) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL11665959 | 0.87 | TSHR (0.77) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL4203434 | 0.86 | TSHR (0.76) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL9339256 | 0.86 | TSHR (0.76) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL10325817 | 0.86 | KDM4E (0.76) | TSHRCYP1A2CYP2C19MAPK1HPGD | |
| SCHEMBL4459274 | 0.85 | TSHR (1.00) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL11045073 | 0.85 | F10 (0.77) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL29378181 | 0.85 | TSHR (1.00) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL9337435 | 0.84 | TSHR (0.68) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A | |
| SCHEMBL6242064 | 0.84 | TSHR (0.80) | TSHRCYP1A2CYP2D6CYP2C19APOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122194-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION | 2025-04-17 | — | — | US | disclosed |
| US-12187722-B2 | Small molecule inhibitors of TEAD transcription factors | THE GENERAL HOSPITAL CORPORATION (US) | 2025-01-07 | — | — | US | disclosed |
| US-20230113085-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION | 2023-04-13 | — | — | US | disclosed |
| EP-3937943-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | The General Hospital Corporation (US) | 2022-01-19 | — | — | EP | disclosed |
| CN-113811300-A | Novel small molecule inhibitors of TEAD transcription factor | 总医院公司 | 2021-12-17 | — | — | CN | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12187722-B2 | Small molecule inhibitors of TEAD transcription factors | TEAD1, TEAD2, TEAD3 | TSHR 2808/4885CYP1A2 4382/4885CYP2D6 4626/4885 |
| US-20250122194-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | TEAD1, TEAD2, TEAD3 | TSHR 2931/4885CYP1A2 4522/4885CYP2D6 4682/4885 |
| US-20230113085-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | TEAD1, TEAD2, TEAD3 | TSHR 2931/4885CYP1A2 4522/4885CYP2D6 4682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.