Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.70 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11665959 | 0.90 | TSHR (0.77) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL6720874 | 0.89 | TSHR (0.73) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL4203434 | 0.85 | TSHR (0.76) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL9339256 | 0.85 | TSHR (0.76) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL21446855 | 0.85 | KDM4E (0.77) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL11045073 | 0.84 | F10 (0.77) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL22445033 | 0.84 | TSHR (0.74) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL4459274 | 0.84 | TSHR (1.00) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL29378181 | 0.84 | TSHR (1.00) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL5928817 | 0.84 | TSHR (0.80) | TSHRKDM4EHSD17B10CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315695-A2 | BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS | Telik, Inc. (US) | 2003-06-04 | — | — | EP | claimed |
| US-20020103183-A1 | Benzene tricarboxylic acid derivatives as insulin receptor activators | TELIK, INC. | 2002-08-01 | — | — | US | claimed |
| WO-2002020464-A2 | BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS | TELIK, INC. (US) | 2002-03-14 | — | — | WO | claimed |
| EP-1315695-B1 | BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS | TELIK INC (US) | 2005-07-13 | — | — | EP | disclosed |
| US-6600069-B2 | Insulin receptor kinase activators; treating hyperglycemia; 4-((3,5-bis(N-(4-sulfophenyl)carbamoyl)phenyl)carbonylamino)-benzenesulfonic acid, for example | TELIK, INC. | 2003-07-29 | — | — | US | disclosed |
| EP-1315695-A2 | BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS | Telik, Inc. (US) | 2003-06-04 | — | — | EP | disclosed |
| US-20020103183-A1 | Benzene tricarboxylic acid derivatives as insulin receptor activators | TELIK, INC. | 2002-08-01 | — | — | US | disclosed |
| WO-2002020464-A2 | BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS | TELIK, INC. (US) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103183-A1 | Benzene tricarboxylic acid derivatives as insulin receptor activators | GPR119, INSR, IRS1 | TSHR 432/4885KDM4E 3770/4885HSD17B10 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.