Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22448323 | 0.82 | CYP3A4 (0.41) | KCNH2CHEK2FLT1KDM4ENPSR1 | |
| SCHEMBL16441112 | 0.80 | TLR8 (0.52) | TLR8TLR7 | |
| SCHEMBL22448336 | 0.80 | ELANE (0.35) | TLR8TLR7ELANE | |
| SCHEMBL22448322 | 0.71 | PRKCI (0.43) | KDM4ETLR8TLR7SLC29A1ELANE | |
| SCHEMBL22448326 | 0.68 | PRKCI (0.49) | KCNH2CHEK2FLT1KDM4ENPSR1 | |
| SCHEMBL17829983 | 0.64 | PRKCI (0.51) | TLR8TLR7 | |
| SCHEMBL20668004 | 0.64 | ALDH1A1 (0.41) | CHEK2FLT1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL20667974 | 0.63 | KDM4E (0.51) | CHEK2FLT1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL16441151 | 0.61 | CRHR1 (0.43) | TLR8TLR7ELANE | |
| SCHEMBL20667999 | 0.60 | JAK2 (0.40) | CHEK2FLT1KDM4ETLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3404031-B1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-09-23 | — | — | EP | disclosed |