Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.32 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16441151 | 0.83 | CRHR1 (0.43) | ELANETLR8TLR7CRHR1ADORA3 | |
| SCHEMBL17829996 | 0.81 | TLR8 (0.52) | ELANETLR8TLR7ADORA1 | |
| SCHEMBL22448348 | 0.80 | KCNH2 (0.36) | ELANETLR8TLR7 | |
| SCHEMBL23472401 | 0.63 | TRPM8 (0.35) | TLR8TLR7 | |
| SCHEMBL22448323 | 0.62 | CYP3A4 (0.41) | TLR8TLR7CRHR1 | |
| SCHEMBL22448325 | 0.59 | TLR8 (0.42) | TLR8TLR7 | |
| SCHEMBL17829984 | 0.59 | TLR8 (0.56) | TLR8TLR7ADORA2AADORA1 | |
| SCHEMBL1937502 | 0.56 | TLR8 (0.41) | ELANETLR8TLR7CRHR1HCAR3 | |
| SCHEMBL26536283 | 0.55 | NPC1 (0.38) | ELANETLR8TLR7HCAR3 | |
| SCHEMBL23472519 | 0.55 | TLR8 (0.40) | ELANETLR8TLR7CRHR1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3404031-B1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-09-23 | — | — | EP | disclosed |