Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 9/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 9/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23749845 | 0.79 | GABRA1 (0.39) | GABRA1GABRB1P2RX3P2RX2 | |
| SCHEMBL26064376 | 0.77 | NOS3 (0.44) | POLBGAAGFERUHRF1GABRA1 | |
| SCHEMBL25841159 | 0.76 | NOS3 (0.38) | POLBGAAGFERUHRF1P2RX3 | |
| SCHEMBL25613928 | 0.76 | GABRA1 (0.37) | GABRA1GABRB1P2RX3P2RX2 | |
| SCHEMBL15614474 | 0.76 | GABRA1 (0.37) | POLBGAAGFERUHRF1GABRA1 | |
| SCHEMBL25843328 | 0.76 | UHRF1 (0.52) | POLBGAAGFERUHRF1P2RX3 | |
| SCHEMBL22448726 | 0.75 | POLB (0.42) | POLBGAAGFERP2RX3P2RX2 | |
| SCHEMBL22448601 | 0.74 | GABRA1 (0.45) | GABRA1GABRB1KMT2A | |
| SCHEMBL12132818 | 0.74 | P2RX3 (0.38) | POLBGAAGFERUHRF1GABRA1 | |
| SCHEMBL25927987 | 0.74 | GABRA1 (0.35) | POLBGAAGFERUHRF1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3712144-A1 | P2X3 AND/OR P2X2/3 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | Beijing Tide Pharmaceutical Co., Ltd. (CN) | 2020-09-23 | — | — | EP | disclosed |