Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | IDE | P14735 | 2/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452659 | 0.82 | ALDH1A1 (0.40) | ALDH1A1EPHX2SERPINE1SMN1; SMN2HIF1A | |
| SCHEMBL22453417 | 0.82 | CYP11B1 (0.48) | ALDH1A1EPHX2HIF1AEPAS1MAPT | |
| SCHEMBL22452687 | 0.79 | EPHX2 (0.53) | EPHX2SERPINE1SMN1; SMN2CYP2C9 | |
| SCHEMBL22452684 | 0.75 | HIF1A (0.52) | ALDH1A1EPHX2SERPINE1HIF1AEPAS1 | |
| SCHEMBL22452985 | 0.73 | SERPINE1 (0.43) | ALDH1A1EPHX2SERPINE1SMN1; SMN2HIF1A | |
| SCHEMBL22452785 | 0.73 | MAPT (0.48) | ALDH1A1SERPINE1SMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL22453002 | 0.73 | DHODH (0.50) | ALDH1A1SERPINE1SMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL22453415 | 0.72 | SERPINE1 (0.53) | ALDH1A1EPHX2SERPINE1SMN1; SMN2HIF1A | |
| SCHEMBL22453380 | 0.71 | ALDH1A1 (0.46) | ALDH1A1EPHX2SERPINE1HIF1AEPAS1 | |
| SCHEMBL22452686 | 0.71 | KDM5A (0.50) | SERPINE1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |