Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.44 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | MDH1 | P40925 | 2/20 | 0.43 |
| ▸ | MDH2 | P40926 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453037 | 0.89 | HIF1A (0.50) | HIF1AEPAS1CASP2LMNAHTT | |
| SCHEMBL22453481 | 0.88 | PGR (0.46) | HIF1AEPAS1CASP2MDH1MDH2 | |
| SCHEMBL22453789 | 0.88 | KMT2A (0.41) | HIF1AEPAS1CASP2MDH1MDH2 | |
| SCHEMBL22452673 | 0.87 | PGR (0.50) | HIF1AEPAS1MDH1MDH2LMNA | |
| SCHEMBL22453367 | 0.85 | ACACB (0.38) | HIF1AEPAS1CASP2MDH1MDH2 | |
| SCHEMBL22452670 | 0.85 | LMNA (0.41) | HIF1AEPAS1CASP2MDH1MDH2 | |
| SCHEMBL22453558 | 0.84 | CNR2 (0.47) | HIF1AEPAS1CASP2MDH1MDH2 | |
| SCHEMBL22452675 | 0.83 | MDH1 (0.39) | HIF1AEPAS1CASP2MDH1MDH2 | |
| SCHEMBL22453740 | 0.83 | NPSR1 (0.42) | HIF1AEPAS1CASP2MDH1MDH2 | |
| SCHEMBL22452516 | 0.81 | HIF1A (0.47) | HIF1AEPAS1CASP2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |