Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 7/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453323 | 0.99 | FAAH (0.63) | FAAHKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL22453093 | 0.87 | CNR2 (0.57) | FAAHKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL22453497 | 0.81 | SERPINE1 (0.57) | MAPTEPHX2FABP4 | |
| SCHEMBL22452527 | 0.81 | SERPINE1 (0.57) | MAPTEPHX2FABP4 | |
| SCHEMBL22453070 | 0.81 | DHODH (0.58) | FAAHKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL1421026 | 0.80 | FAAH (1.00) | FAAHKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL10928771 | 0.79 | KDM4E (0.72) | FAAHKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL22452498 | 0.79 | HIF1A (0.60) | KDM4EALDH1A1MAPTEPHX2FABP4 | |
| SCHEMBL31555348 | 0.79 | HIF1A (0.60) | KDM4EALDH1A1MAPTEPHX2FABP4 | |
| SCHEMBL28355432 | 0.78 | FAAH (0.78) | FAAHKDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |