Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453723 | 0.89 | CYP1A2 (0.35) | DHODHKMT2ASMN1; SMN2 | |
| SCHEMBL22453294 | 0.86 | KDM4E (0.41) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL22453086 | 0.80 | SERPINE1 (0.35) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL22453348 | 0.76 | KMT2A (0.42) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL22453585 | 0.75 | CYP1A2 (0.38) | KDM4EHTTKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL22453088 | 0.74 | DHODH (0.42) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL22452775 | 0.73 | KDM4E (0.42) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL22453642 | 0.72 | KDM4C (0.40) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL22453373 | 0.72 | PSMB5 (0.38) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL22452777 | 0.70 | KMT2A (0.50) | KDM4EGLAHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |