Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 3/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.33 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452936 | 0.90 | NR1H4 (0.35) | KMT2ASMN1; SMN2DHODHTP53ALDH1A1 | |
| SCHEMBL22452558 | 0.89 | KDM4C (0.42) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL22453088 | 0.83 | DHODH (0.42) | SERPINE1KDM4EGLAHTTKMT2A | |
| SCHEMBL22452822 | 0.80 | DHODH (0.39) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL22452775 | 0.78 | KDM4E (0.42) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL22453576 | 0.78 | CYP1A2 (0.40) | KDM4EKMT2ASMN1; SMN2KDM4CLMNA | |
| SCHEMBL22453348 | 0.76 | KMT2A (0.42) | SERPINE1KDM4EGLAHTTKMT2A | |
| SCHEMBL22453636 | 0.76 | KDM1A (0.40) | SERPINE1KMT2ADHODHS1PR1ALDH1A1 | |
| SCHEMBL22453296 | 0.74 | HDAC3 (0.47) | SERPINE1S1PR1 | |
| SCHEMBL22453370 | 0.71 | BACE1 (0.36) | ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |