Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | MDH1 | P40925 | 2/20 | 0.42 |
| ▸ | MDH2 | P40926 | 2/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452980 | 0.89 | NPC1 (0.46) | HIF1ANPC1EPAS1EPHX2PGR | |
| SCHEMBL22452673 | 0.86 | PGR (0.50) | HIF1ANPC1EPAS1PGRMDH1 | |
| SCHEMBL22452503 | 0.81 | MAPT (0.58) | HIF1ANPC1EPAS1EPHX2MDH1 | |
| SCHEMBL22453783 | 0.81 | SIRT2 (0.49) | HIF1ANPC1EPAS1EPHX2PGR | |
| SCHEMBL22453109 | 0.81 | HIF1A (0.64) | HIF1ANPC1EPAS1EPHX2PGR | |
| SCHEMBL22453751 | 0.80 | HPGD (0.55) | HIF1ANPC1EPAS1EPHX2KMT2A | |
| SCHEMBL22452577 | 0.77 | HIF1A (0.51) | HIF1ANPC1EPAS1EPHX2PGR | |
| SCHEMBL22453221 | 0.77 | HIF1A (0.51) | HIF1ANPC1EPAS1EPHX2PGR | |
| SCHEMBL22452501 | 0.77 | MAPT (0.55) | HIF1ANPC1EPAS1EPHX2MDH1 | |
| SCHEMBL22452507 | 0.75 | MAPT (0.53) | HIF1ANPC1EPAS1EPHX2MDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |