Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453356 | 0.88 | HTR2C (0.32) | HTR2ASLC6A4KCNH2FFAR1HTR2C | |
| SCHEMBL22453159 | 0.87 | PDE7A (0.43) | HTR2ASLC6A4FFAR1PDE7AKMT2A | |
| SCHEMBL22453130 | 0.79 | EPHX2 (0.39) | KMT2AEPHX2MEN1 | |
| SCHEMBL22453398 | 0.78 | KMT2A (0.37) | SCN9AKMT2AEPHX2MEN1 | |
| SCHEMBL22452447 | 0.78 | KMT2A (0.41) | SCN9AKMT2AMEN1 | |
| SCHEMBL2730836 | 0.76 | EPHX2 (0.34) | KMT2AEPHX2MEN1 | |
| SCHEMBL22452671 | 0.73 | SLC6A4 (0.39) | HTR2ASLC6A4KCNH2KMT2AEPHX2 | |
| SCHEMBL13295195 | 0.71 | PDE7A (0.49) | HTR2ASLC6A4KCNH2SCN9APDE7A | |
| SCHEMBL11018978 | 0.71 | ALDH1A1 (0.50) | HTR2ASLC6A4KCNH2SCN9APDE7A | |
| SCHEMBL22453702 | 0.70 | PTPN11 (0.45) | KMT2AEPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |