Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PNLIP | P16233 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | NR0B2 | Q15466 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453356 | 0.88 | HTR2C (0.32) | PDE7AFFAR1HTR2ASLC6A4MEN1 | |
| SCHEMBL22453360 | 0.87 | HTR2A (0.33) | PDE7AFFAR1HTR2ASLC6A4MEN1 | |
| SCHEMBL22453327 | 0.83 | ALDH1A1 (0.55) | PDE7AFFAR1PGRALDH1A1LMNA | |
| SCHEMBL22453130 | 0.80 | EPHX2 (0.39) | PGRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL22452671 | 0.78 | SLC6A4 (0.39) | ALDH1A1LMNAHTR2ASLC6A4MEN1 | |
| SCHEMBL22453128 | 0.78 | LMNA (0.56) | PGRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2730836 | 0.75 | EPHX2 (0.34) | MEN1KMT2AEPHX2PTPN11NR0B2 | |
| SCHEMBL22453463 | 0.73 | CRHBP (0.39) | ALDH1A1MEN1KMT2AEPHX2SMN1; SMN2 | |
| SCHEMBL22453702 | 0.73 | PTPN11 (0.45) | LMNAMEN1KMT2AEPHX2PTPN11 | |
| SCHEMBL2707940 | 0.73 | RXRA (0.48) | PGRALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |