Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452447 | 0.94 | KMT2A (0.41) | KMT2ALMNAP2RX7SCN9ATOP1 | |
| SCHEMBL22453441 | 0.91 | TDP1 (0.37) | KMT2ATDP1LMNAP2RX7TOP1 | |
| SCHEMBL22453332 | 0.85 | LMNA (0.41) | KMT2ALMNAP2RX7TOP1KDM4E | |
| SCHEMBL22452454 | 0.83 | LMNA (0.40) | KMT2ALMNAP2RX7SCN9ATOP1 | |
| SCHEMBL22453440 | 0.83 | TOP1 (0.39) | KMT2ATDP1LMNATOP1KDM4E | |
| SCHEMBL22453360 | 0.78 | HTR2A (0.33) | KMT2ASCN9AMEN1EPHX2 | |
| SCHEMBL22452986 | 0.77 | AKR1C3 (0.40) | KMT2ATDP1LMNATOP1KDM4E | |
| SCHEMBL22453760 | 0.75 | RAB9A (0.40) | KMT2ATOP1GAAMAPTMEN1 | |
| SCHEMBL22453074 | 0.74 | PARP1 (0.41) | KMT2ATDP1LMNAMAPTMEN1 | |
| SCHEMBL22453159 | 0.72 | PDE7A (0.43) | KMT2ALMNAKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |