SCHEMBL22453573

SCHEMBL22453573

Nc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.58
L3MBTL1 Q9Y468 2/20 0.53
POLB P06746 4/20 0.50
MEN1 O00255 4/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
LMNA P02545 1/20 0.50
MRGPRX4 Q96LA9 1/20 0.49
KDM4E B2RXH2 5/20 0.47
RAB9A P51151 1/20 0.47
KEAP1 Q14145 1/20 0.46
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C19 P33261 1/20 0.44
HPGD P15428 1/20 0.43
MAPT P10636 1/20 0.42
TSHR P16473 1/20 0.41
FFAR1 O14842 2/20 0.41
ALDH1A1 P00352 1/20 0.40
BRCA1 P38398 1/20 0.40
HBB P68871 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10716542 0.89 KMT2A (0.66) KMT2AL3MBTL1POLBMEN1SMN1; SMN2
SCHEMBL21186229 0.81 KMT2A (0.59) KMT2AL3MBTL1POLBMEN1KDM4E
SCHEMBL22453568 0.81 KDM4E (0.51) KMT2AL3MBTL1POLBMEN1SMN1; SMN2
SCHEMBL1200417 0.81 KDM4E (0.52) KMT2AL3MBTL1POLBMEN1LMNA
SCHEMBL8159388 0.81 KMT2A (0.52) KMT2AL3MBTL1POLBMEN1SMN1; SMN2
SCHEMBL11386499 0.80 L3MBTL1 (0.75) KMT2AL3MBTL1POLBMEN1SMN1; SMN2
SCHEMBL22453575 0.79 KMT2A (0.49) KMT2AL3MBTL1POLBMEN1SMN1; SMN2
SCHEMBL10984838 0.78 MAPT (0.64) KMT2AL3MBTL1POLBMEN1SMN1; SMN2
SCHEMBL28481117 0.78 KMT2A (0.59) KMT2AL3MBTL1POLBMEN1SMN1; SMN2
SCHEMBL9582439 0.78 FFAR1 (0.58) KMT2AL3MBTL1MEN1LMNAMRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4097111-B9 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2025-10-29 EP disclosed
US-12415815-B2 Pyrido[2,3-e]oxazine derivatives as agricultural chemicals GLOBACHEM NV (BE) 2025-09-16 US disclosed
EP-4097111-B1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2025-07-23 EP disclosed
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2023-05-18 US disclosed
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2023-05-18 US disclosed
WO-2021151919-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2021-08-05 WO disclosed
WO-2020190774-A1 NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS THE GENERAL HOSPITAL CORPORATION (US) 2020-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS PNPO, HPD, PDXK KMT2A 3565/4885L3MBTL1 3495/4885POLB 3680/4885
US-12415815-B2 Pyrido[2,3-e]oxazine derivatives as agricultural chemicals PNPO, HPD, PDXK KMT2A 3565/4885L3MBTL1 3495/4885POLB 3680/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.