Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GFER | P55789 | 4/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LGMN | Q99538 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631313 | 0.87 | LMNA (0.61) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL20631 | 0.85 | MAPT (0.61) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL22452584 | 0.84 | ALDH1A1 (0.69) | MAPTALDH1A1KDM4EGAAKMT2A | |
| Hydrochloric Acid SCHEMBL16209945 | 0.83 | MAPT (0.65) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL17602226 | 0.83 | GAA (0.49) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL29331438 | 0.80 | LMNA (0.52) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL14320289 | 0.80 | PIK3R1 (0.59) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL9094196 | 0.80 | SLC2A1 (0.67) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL4386393 | 0.78 | MAPT (0.64) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL13370287 | 0.76 | MAPT (0.50) | MAPTALDH1A1KDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |