Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453342 | 0.82 | LRRK2 (0.46) | LRRK2TMPRSS4PTGS1P2RX1AR | |
| SCHEMBL22445869 | 0.77 | JAK2 (0.41) | LRRK2BRAF | |
| SCHEMBL22446008 | 0.70 | CFTR (0.42) | CFTR | |
| SCHEMBL21314145 | 0.69 | ASPH (0.44) | HSD17B10 | |
| SCHEMBL22453892 | 0.68 | LRRK2 (0.55) | LRRK2CFTRHDAC1HDAC8HDAC6 | |
| SCHEMBL5668547 | 0.66 | PTGS1 (0.68) | TMPRSS4PTGS1P2RX1TRPV1 | |
| SCHEMBL22452996 | 0.66 | LRRK2 (0.50) | LRRK2BRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL1161194 | 0.64 | FADS1 (0.51) | TMPRSS4PTGS1P2RX1HDAC1 | |
| SCHEMBL13318839 | 0.64 | CACNA1H (0.39) | AR | |
| SCHEMBL22453384 | 0.63 | LRRK2 (0.50) | LRRK2BRAFHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |