Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453774 | 0.96 | LMNA (0.47) | LMNAMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL22452983 | 0.90 | MEN1 (0.48) | LMNAKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL22453525 | 0.90 | MAPT (0.50) | LMNAKMT2AMEN1HSD17B10MAPT | |
| SCHEMBL22452725 | 0.86 | MEN1 (0.46) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL22453772 | 0.86 | MAPT (0.48) | LMNAMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL22453477 | 0.86 | LMNA (0.42) | LMNAMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL22453680 | 0.84 | SERPINE1 (0.53) | LMNAKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL22452790 | 0.82 | SERPINE1 (0.51) | LMNAKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL22452486 | 0.79 | HIF1A (0.50) | LMNAKMT2AMEN1KDM4EMAPT | |
| SCHEMBL22452503 | 0.79 | MAPT (0.58) | LMNAKDM4EHSD17B10MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |