Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453773 | 0.91 | HIF1A (0.45) | MAPTALOX15MEN1KMT2AGAA | |
| SCHEMBL22453449 | 0.89 | HIF1A (0.51) | MEN1KMT2AGAAEPHX2NPC1 | |
| SCHEMBL22452503 | 0.88 | MAPT (0.58) | MAPTALOX15LMNAEPHX2NPC1 | |
| SCHEMBL22453774 | 0.88 | LMNA (0.47) | MAPTALOX15MEN1KMT2AGAA | |
| SCHEMBL22453775 | 0.86 | LMNA (0.49) | MAPTALOX15MEN1KMT2AGAA | |
| SCHEMBL22453172 | 0.85 | CNR2 (0.53) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL22452507 | 0.84 | MAPT (0.53) | MAPTALOX15MEN1KMT2AEPHX2 | |
| SCHEMBL22452652 | 0.84 | EPHX2 (0.61) | MAPTALOX15LMNAEPHX2NPC1 | |
| SCHEMBL22452501 | 0.83 | MAPT (0.55) | MAPTALOX15EPHX2NPC1HPGD | |
| SCHEMBL22452577 | 0.82 | HIF1A (0.51) | MAPTALOX15ELANEPRTN3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |