Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 1/20 | 0.65 |
| ▸ | TUBB | P07437 | 1/20 | 0.65 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.65 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.65 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.65 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.65 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.65 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.65 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.65 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.65 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.65 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.65 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.65 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.65 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6192534 | 0.92 | TUBB4A (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29409455 | 0.86 | TUBB4A (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5346065 | 0.86 | TUBB4A (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5569350 | 0.84 | TUBB4A (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5982035 | 0.81 | TUBB4A (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5572473 | 0.80 | TUBB4A (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Indibulin SCHEMBL3165856 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Indibulin SCHEMBL29355017 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2252440 | 0.78 | TUBB4A (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5573795 | 0.78 | TUBB4A (0.56) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008324-B2 | Antitumor agents; N-propargyl-N-(2-methyl-6-quinolyl)-[1-(4-chlorobenzyl)indol-3-yl]glyoxylamide | AETERNA ZENTARIS GMBH (DE) | 2011-08-30 | — | — | US | disclosed |
| US-8008324-B2 | Antitumor agents; N-propargyl-N-(2-methyl-6-quinolyl)-[1-(4-chlorobenzyl)indol-3-yl]glyoxylamide | AETERNA ZENTARIS GMBH (DE) | 2011-08-30 | — | — | US | disclosed |
| US-8008324-B2 | Antitumor agents; N-propargyl-N-(2-methyl-6-quinolyl)-[1-(4-chlorobenzyl)indol-3-yl]glyoxylamide | AETERNA ZENTARIS GMBH (DE) | 2011-08-30 | — | — | US | disclosed |
| US-7989453-B2 | Antitumor agents; for example, N-(2-methyl-6-quinolyl)-[1-(4-chlorobenzyl)indole-3-yl]glyoxylamide | AETERNA ZENTARIS GMBH (DE) | 2011-08-02 | — | — | US | disclosed |
| US-7989453-B2 | Antitumor agents; for example, N-(2-methyl-6-quinolyl)-[1-(4-chlorobenzyl)indole-3-yl]glyoxylamide | AETERNA ZENTARIS GMBH (DE) | 2011-08-02 | — | — | US | disclosed |
| US-7989453-B2 | Antitumor agents; for example, N-(2-methyl-6-quinolyl)-[1-(4-chlorobenzyl)indole-3-yl]glyoxylamide | AETERNA ZENTARIS GMBH (DE) | 2011-08-02 | — | — | US | disclosed |
| EP-2163552-A1 | Indole derivatives and their use as antitumor agents | AEterna Zentaris GmbH (DE) | 2010-03-17 | — | — | EP | disclosed |
| EP-2163552-A1 | Indole derivatives and their use as antitumor agents | AEterna Zentaris GmbH (DE) | 2010-03-17 | — | — | EP | disclosed |
| EP-2163552-A1 | Indole derivatives and their use as antitumor agents | AEterna Zentaris GmbH (DE) | 2010-03-17 | — | — | EP | disclosed |
| EP-1939195-A1 | New indole derivatives and their use as medicine | AEterna Zentaris GmbH (DE) | 2008-07-02 | — | — | EP | disclosed |
| EP-1641777-A1 | INDOLE DERIVATIVES WITH APOPTOSIS-INDUCING EFFECT | Zentaris GmbH (DE) | 2006-04-05 | — | — | EP | disclosed |
| EP-1595878-A1 | INDOLE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY | Zentaris GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2005014542-A2 | NOVEL N-SUBSTITUTED INDOLYL-3-GLYOXYLIC ACID AMIDES, USE THEREOF AS A MEDICAMENT AGAINST CANCER, AND METHOD FOR THE PRODUCTION THEREOF | ZENTARIS GMBH (DE) | 2005-02-17 | — | — | WO | disclosed |
| US-20050020636-A1 | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation | ZENTARIS GMBH (DE) | 2005-01-27 | — | — | US | disclosed |
| US-20040266762-A1 | Indole derivatives having an apoptosis-inducing effect | AETERNA ZENTARIS GMBH (DE) | 2004-12-30 | — | — | US | disclosed |
| WO-2004108702-A1 | INDOLE DERIVATIVES WITH APOPTOSIS-INDUCING EFFECT | ZENTARIS GMBH (DE) | 2004-12-16 | — | — | WO | disclosed |
| EP-1484329-A1 | Indole derivatives with apoptosis inducing activity | Zentaris GmbH (DE) | 2004-12-08 | — | — | EP | disclosed |
| US-20030100597-A1 | Novel indole derivatives and their use as medicaments | AETERNA ZENTARIS GMBH (DE) | 2003-05-29 | — | — | US | disclosed |
| EP-1309585-A2 | NOVEL INDOLE DERIVATIVES AND THEIR USE AS MEDICAMENTS | Zentaris AG (DE) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002010152-A2 | NOVEL INDOLE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ZENTARIS AG (DE) | 2002-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266762-A1 | Indole derivatives having an apoptosis-inducing effect | BAD, API5, AIFM1 | TUBB4A 1171/4885TUBB 1105/4885TUBA3C 1897/4885 |
| US-20050020636-A1 | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation | IDO2, IDO1, AGXT | TUBB4A 585/4885TUBB 391/4885TUBA3C 308/4885 |
| US-20030100597-A1 | Novel indole derivatives and their use as medicaments | IDO1, TPH1, IDO2 | TUBB4A 609/4885TUBB 419/4885TUBA3C 1396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.