SCHEMBL29409455

SCHEMBL29409455

O=C(Nc1ccc2ncccc2c1)C(=O)c1cn(Cc2ccc(Cl)cc2)c2ccccc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 1/20 0.68
TUBB P07437 1/20 0.68
TUBA3C P0DPH7 1/20 0.68
TUBA1B P68363 1/20 0.68
TUBA4A P68366 1/20 0.68
TUBB4B P68371 1/20 0.68
TUBB3 Q13509 1/20 0.68
TUBB2A Q13885 1/20 0.68
TUBB8 Q3ZCM7 1/20 0.68
TUBA3E Q6PEY2 1/20 0.68
TUBA1A Q71U36 1/20 0.68
TUBA1C Q9BQE3 1/20 0.68
TUBB6 Q9BUF5 1/20 0.68
TUBB2B Q9BVA1 1/20 0.68
TUBB1 Q9H4B7 1/20 0.68
HTT P42858 2/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 1/20 0.48
CNR2 P34972 1/20 0.46
MAPT P10636 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5346065 1.00 TUBB4A (0.68) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5573795 0.91 TUBB4A (0.56) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL2245487 0.86 TUBB4A (0.65) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5570405 0.82 TUBB4A (0.68) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Indibulin SCHEMBL29355017 0.81 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Indibulin SCHEMBL3165856 0.81 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5573030 0.81 TUBB4A (0.65) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5572473 0.81 TUBB4A (0.65) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5569338 0.80 TUBB4A (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5569320 0.80 TUBB4A (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656588-A2 ENHANCED NANOPARTICLE DELIVERY SYSTEMS Children's Hospital Medical Center (US) 2025-12-03 EP claimed
US-20250340879-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER CHILDRENS HOSPITAL MED CT (US) 2025-11-06 US claimed
US-12378550-B2 Compositions and methods for nucleic acid transfer CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2025-08-05 US claimed
EP-4702027-A1 4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZINE C-NUCLEOSIDE COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS GILEAD SCIENCES, INC. (US) 2026-03-04 EP disclosed
US-20260000618-A1 PHARMACEUTICAL FORMULATIONS AND USES THEREOF GILEAD SCIENCES INC (US) 2026-01-01 US disclosed
EP-4656588-A2 ENHANCED NANOPARTICLE DELIVERY SYSTEMS Children's Hospital Medical Center (US) 2025-12-03 EP disclosed
US-12485088-B2 Rapidly-orodispersible tablets having an interior cavity Aprecia Pharmaceuticals LLC (US) 2025-12-02 US disclosed
US-20250340879-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER CHILDRENS HOSPITAL MED CT (US) 2025-11-06 US disclosed
US-12448383-B2 Compounds and methods for treatment of viral infections GILEAD SCIENCES, INC. (US) 2025-10-21 US disclosed
US-20250296936-A1 SARS-COV2 MAIN PROTEASE INHIBITORS GILEAD SCIENCES, INC. 2025-09-25 US disclosed
US-12410183-B2 Sars-cov2 main protease inhibitors GILEAD SCIENCES, INC. (US) 2025-09-09 US disclosed
US-20230279015-A1 COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS GILEAD SCIENCES, INC. 2023-09-07 US disclosed
US-20230279013-A1 COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS GILEAD SCIENCES, INC. 2023-09-07 US disclosed
US-20230270665-A1 RAPIDLY-ORODISPERSIBLE TABLETS HAVING AN INTERIOR CAVITY Aprecia Pharmaceuticals LLC 2023-08-31 US disclosed
EP-4171518-A1 RAPIDLY-ORODISPERSIBLE TABLETS HAVING AN INTERIOR CAVITY Aprecia Pharmaceuticals LLC (US) 2023-05-03 EP disclosed
US-11433022-B2 Rapidly-orodispersible tablets having an in interior cavity Aprecia Pharmaceuticals LLC (US) 2022-09-06 US disclosed
WO-2022125784-A1 ENHANCED NANOPARTICLE DELIVERY SYSTEMS CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2022-06-16 WO disclosed
EP-3981392-A1 CONTROLLED RELEASE DOSAGE FORM Triastek, Inc. (CN) 2022-04-13 EP disclosed
US-11278499-B2 Oral drug dosage form comprising various release profiles Triastek, Inc. (CN) 2022-03-22 US disclosed
US-20220054409-A1 RAPIDLY-ORODISPERSIBLE TABLETS HAVING AN INTERIOR CAVITY Aprecia Pharmaceuticals LLC 2022-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230279015-A1 COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS HAVCR2, EIF2AK2, OAT TUBB4A 717/4885TUBB 490/4885TUBA3C 449/4885
US-20260000618-A1 PHARMACEUTICAL FORMULATIONS AND USES THEREOF PRNP, F7, F5 TUBB4A 3729/4885TUBB 4121/4885TUBA3C 4134/4885
US-11278499-B2 Oral drug dosage form comprising various release profiles CYP2D6, CYP3A7, CYP3A5 TUBB4A 4198/4885TUBB 3862/4885TUBA3C 4438/4885
US-12448383-B2 Compounds and methods for treatment of viral infections HAVCR2, EIF2AK2, OAT TUBB4A 717/4885TUBB 490/4885TUBA3C 449/4885
US-12410183-B2 Sars-cov2 main protease inhibitors ACE2, TMPRSS2, ACE TUBB4A 4847/4885TUBB 4797/4885TUBA3C 4165/4885
US-20250340879-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER SNRPE, RNASE1, POLRMT TUBB4A 654/4885TUBB 349/4885TUBA3C 549/4885
US-20250296936-A1 SARS-COV2 MAIN PROTEASE INHIBITORS ACE2, TMPRSS2, ACE TUBB4A 4813/4885TUBB 4724/4885TUBA3C 3944/4885
US-20230279013-A1 COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS HAVCR2, EIF2AK2, OAT TUBB4A 717/4885TUBB 490/4885TUBA3C 449/4885
US-12378550-B2 Compositions and methods for nucleic acid transfer SNRPE, RNASE1, POLRMT TUBB4A 654/4885TUBB 349/4885TUBA3C 549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.