Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245702 | 0.87 | MMP12 (0.56) | CA2CA1F2F10PRSS1 | |
| SCHEMBL2246916 | 0.83 | CA2 (0.58) | CA2CA1KMT2ARAB9ANPSR1 | |
| SCHEMBL2245325 | 0.83 | CA2 (0.69) | CA2CA1F2KMT2ARAB9A | |
| SCHEMBL2246061 | 0.83 | CA2 (0.69) | CA2CA1F2KMT2ARAB9A | |
| SCHEMBL2246549 | 0.81 | RXRA (0.58) | CA2CA1F2F10PRSS1 | |
| SCHEMBL2251027 | 0.79 | CA2 (0.51) | CA2CA1MMP2MMP9 | |
| SCHEMBL3580201 | 0.79 | KLKB1 (0.54) | MMEALDH1A1L3MBTL1RAB9ANPC1 | |
| SCHEMBL5260686 | 0.79 | CA2 (0.70) | CA2CA1KMT2AMRGPRX4MMP2 | |
| SCHEMBL5260684 | 0.79 | CA2 (0.70) | CA2CA1KMT2AMRGPRX4MMP2 | |
| SCHEMBL27708291 | 0.77 | CA2 (0.48) | CA2CA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |