Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245705 | 0.87 | CA2 (0.53) | MMECA1TDP1LMNAF2 | |
| SCHEMBL3580201 | 0.85 | KLKB1 (0.54) | MMP12MMEADAMTS5ADAMTS4MMP2 | |
| SCHEMBL2246912 | 0.83 | MMP12 (0.58) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2252056 | 0.83 | ADAMTS5 (0.69) | MMP12MMEADAMTS5ADAMTS4TDP1 | |
| SCHEMBL2247531 | 0.83 | ADAMTS5 (0.52) | MMP12MMEADAMTS5ADAMTS4MMP2 | |
| SCHEMBL2245321 | 0.83 | MMP12 (0.76) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2246054 | 0.83 | MMP12 (0.76) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2246545 | 0.81 | MMP12 (0.61) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2251026 | 0.79 | MMP12 (0.57) | MMP12HPGDSADAMTS5ADAMTS4PTPN1 | |
| SCHEMBL10518630 | 0.79 | HPGDS (0.69) | MMP12CA1CA12CA9HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |