SCHEMBL2246322

SCHEMBL2246322

O=C(Nc1ccccc1)Nc1ccc(O)c(-c2nc3ccccc3o2)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.67
THRB P10828 3/20 0.67
KDM4E B2RXH2 4/20 0.66
HTT P42858 2/20 0.66
TDP1 Q9NUW8 1/20 0.66
HSD17B10 Q99714 3/20 0.60
TP53 P04637 2/20 0.60
NPSR1 Q6W5P4 1/20 0.60
KDM6B O15054 1/20 0.60
KDM6A O15550 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.58
LMNA P02545 1/20 0.58
MAPK1 P28482 1/20 0.58
AGPAT2 O15120 1/20 0.56
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
ALDH1A1 P00352 2/20 0.53
POLB P06746 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2251895 0.87 THRB (0.83) MAPTTHRBKDM4EHTTTDP1
SCHEMBL2245965 0.86 MAPT (0.69) MAPTTHRBKDM4EHTTTDP1
SCHEMBL6721055 0.81 RAB9A (0.71) MAPTTHRBKDM4EHTTTDP1
SCHEMBL9330808 0.81 THRB (0.80) MAPTTHRBKDM4EHTTTDP1
SCHEMBL14221889 0.80 KDM6B (0.63) MAPTTHRBKDM4EHTTTDP1
SCHEMBL2246778 0.80 MAPT (0.66) MAPTTHRBKDM4EHTTTDP1
SCHEMBL31631289 0.79 HSD17B10 (0.64) MAPTTHRBKDM4EHTTTDP1
SCHEMBL27934109 0.78 MAPT (0.65) MAPTTHRBKDM4EHTTTDP1
SCHEMBL2246191 0.77 ALDH1A1 (0.76) MAPTKDM4EHSD17B10TP53NPSR1
SCHEMBL6086529 0.77 NPC1 (0.54) MAPTTHRBKDM4EHSD17B10TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-20110196075-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR SABIC INNOVATIVE PLASTICS IP B.V. 2011-08-11 US disclosed
US-20110196075-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR SABIC INNOVATIVE PLASTICS IP B.V. 2011-08-11 US disclosed
US-20110196075-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR SABIC INNOVATIVE PLASTICS IP B.V. 2011-08-11 US disclosed
WO-2008042497-A2 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS USEFUL AS AUTHENTICATION COMPOUNDS IN POLYMER ARTICLES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-04-10 WO disclosed
WO-2008042497-A2 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS USEFUL AS AUTHENTICATION COMPOUNDS IN POLYMER ARTICLES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-04-10 WO disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
WO-2008039587-A1 AUTHENTICATABLE POLYMER ARTICLES COMPRISING BENZOXAZOLE AND BENZOTHIAZOLE AUTHENTICATION COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-04-03 WO disclosed
WO-2008039587-A1 AUTHENTICATABLE POLYMER ARTICLES COMPRISING BENZOXAZOLE AND BENZOTHIAZOLE AUTHENTICATION COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-04-03 WO disclosed
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR CYP4F11, NPY1R, CYP51A1 MAPT 2630/4885THRB 1487/4885KDM4E 2617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.