Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | ITK | Q08881 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22469029 | 0.92 | ITK (0.39) | EGFRITKBRD4PDE4DTYK2 | |
| SCHEMBL20557551 | 0.81 | TYK2 (0.45) | ADORA3ADORA2AMAPTPDE4DTYK2 | |
| SCHEMBL24263379 | 0.80 | TYK2 (0.46) | ADORA3ADORA2ATP53MAPTPDE4D | |
| SCHEMBL20557221 | 0.78 | MAPT (0.39) | ADORA3ADORA2AMAPTPDE4BMEN1 | |
| SCHEMBL20504574 | 0.77 | IDO1 (0.37) | ADORA3ADORA2AMAPTPDE4DTYK2 | |
| SCHEMBL16794637 | 0.76 | TYK2 (0.45) | MKNK2ADORA3ADORA2AMAPTPDE4D | |
| SCHEMBL30392961 | 0.75 | FAAH (0.37) | EGFRERBB3ADORA3ADORA2ATP53 | |
| SCHEMBL26100287 | 0.75 | FAAH (0.37) | EGFRERBB3ADORA3ADORA2ATP53 | |
| SCHEMBL16794693 | 0.75 | MAPT (0.42) | ADORA3ADORA2AMAPTPDE4DPDE4B | |
| SCHEMBL24263290 | 0.75 | GAA (0.37) | MKNK2ADORA3ADORA2AMAPTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3946350-A1 | TYK2 PSEUDOKINASE LIGANDS | Ventyx Biosciences, Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| WO-2020198379-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2020198379-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. (US) | 2020-10-01 | — | — | WO | disclosed |