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SCHEMBL22470105

SCHEMBL22470105

CC(C)(C)OC(=O)N1CCC1C(=O)NC1(c2ccc(F)c(C(F)(F)F)c2)CC1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.42
▸ KCNN4 O15554 3/20 0.41
▸ LMNA P02545 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ NPC1 O15118 1/20 0.40
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ USP30 Q70CQ3 2/20 0.38
▸ EPHX2 P34913 1/20 0.37
▸ PREP P48147 1/20 0.37
▸ WNT3 P56703 2/20 0.37
▸ SFRP1 Q8N474 2/20 0.37
▸ PDE2A O00408 3/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ PTGER4 P35408 1/20 0.36
▸ RET P07949 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29262043 1.00 ALDH1A1 (0.42) ALDH1A1KCNN4LMNANPSR1NPC1
SCHEMBL28670100 0.88 KCNN4 (0.37) ALDH1A1KCNN4LMNANPSR1NPC1
SCHEMBL28670102 0.88 KCNN4 (0.37) ALDH1A1KCNN4LMNANPSR1NPC1
SCHEMBL22470118 0.87 KCNN4 (0.42) ALDH1A1KCNN4LMNANPSR1NPC1
SCHEMBL29358321 0.87 KCNN4 (0.42) ALDH1A1KCNN4LMNANPSR1NPC1
SCHEMBL22470137 0.86 KCNN4 (0.41) KCNN4PDE2APTGER4
SCHEMBL22470140 0.86 KCNN4 (0.41) KCNN4PDE2APTGER4
SCHEMBL28647448 0.82 KCNN4 (0.45) ALDH1A1KCNN4USP30EPHX2PREP
SCHEMBL22470075 0.82 KCNN4 (0.45) ALDH1A1KCNN4USP30EPHX2PREP
SCHEMBL29356136 0.82 KCNN4 (0.45) ALDH1A1KCNN4USP30EPHX2PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12391644-B2 Potassium channel inhibitors SANIONA A/S (DK) 2025-08-19 — — US disclosed
US-20240368077-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA AS (DK) 2024-11-07 — — US disclosed
US-12006289-B2 Potassium channel inhibitors SANIONA A/S (DK) 2024-06-11 — — US disclosed
CN-113631538-B Novel potassium channel inhibitors 萨尼奥纳有限责任公司 2024-05-31 — — CN disclosed
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2022-06-02 — — US disclosed
EP-3941903-A1 NOVEL POTASSIUM CHANNEL INHIBITORS Saniona A/S (DK) 2022-01-26 — — EP disclosed
CN-113631538-A Novel potassium channel inhibitors 萨尼奥纳有限责任公司 2021-11-09 — — CN disclosed
WO-2020193419-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2020-10-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12391644-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 ALDH1A1 2342/4885KCNN4 48/4885LMNA 1211/4885
US-20240368077-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 ALDH1A1 2868/4885KCNN4 57/4885LMNA 1304/4885
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 ALDH1A1 2868/4885KCNN4 57/4885LMNA 1304/4885
US-12006289-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 ALDH1A1 2342/4885KCNN4 48/4885LMNA 1211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.