Sugi Predict

Sugi Predict / Compounds / SCHEMBL28670100

SCHEMBL28670100

SCHEMBL28670100

CC(C)(C)OC(=O)N1CCOC[C@H]1C(=O)NC1(c2ccc(F)c(C(F)(F)F)c2)CC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNN4 O15554 3/20 0.37
▸ F2 P00734 2/20 0.37
▸ F9 P00740 2/20 0.37
▸ F10 P00742 2/20 0.37
▸ F12 P00748 2/20 0.37
▸ PRSS1 P07477 2/20 0.37
▸ PRSS2 P07478 2/20 0.37
▸ F7 P08709 2/20 0.37
▸ PRSS3 P35030 2/20 0.37
▸ ALDH1A1 P00352 1/20 0.36
▸ LGMN Q99538 1/20 0.35
▸ IL1B P01584 1/20 0.35
▸ P2RX7 Q99572 1/20 0.35
▸ PDE2A O00408 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ NR1H2 P55055 1/20 0.34
▸ NR1H3 Q13133 1/20 0.34
▸ PTGER4 P35408 1/20 0.34
▸ PREP P48147 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28670102 1.00 KCNN4 (0.37) KCNN4F2F9F10F12
SCHEMBL29262043 0.88 ALDH1A1 (0.42) KCNN4ALDH1A1PDE2ALMNANPSR1
SCHEMBL22470105 0.88 ALDH1A1 (0.42) KCNN4ALDH1A1PDE2ALMNANPSR1
SCHEMBL22470470 0.87 F2 (0.38) KCNN4F2F9F10F12
SCHEMBL22470473 0.87 F2 (0.38) KCNN4F2F9F10F12
SCHEMBL29261962 0.83 IL1B (0.42) KCNN4IL1BP2RX7NR1H2NR1H3
SCHEMBL29261963 0.83 IL1B (0.42) KCNN4IL1BP2RX7NR1H2NR1H3
SCHEMBL29355246 0.83 IL1B (0.42) KCNN4IL1BP2RX7NR1H2NR1H3
SCHEMBL30823530 0.81 NPC1 (0.40) ALDH1A1LGMNIL1BP2RX7LMNA
SCHEMBL22470118 0.76 KCNN4 (0.42) KCNN4ALDH1A1PDE2ALMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260049054-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA AS (DK) 2026-02-19 — — US disclosed
US-12391644-B2 Potassium channel inhibitors SANIONA A/S (DK) 2025-08-19 — — US disclosed
EP-3941903-B1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA AS (DK) 2025-07-16 — — EP disclosed
US-20240368077-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA AS (DK) 2024-11-07 — — US disclosed
US-12006289-B2 Potassium channel inhibitors SANIONA A/S (DK) 2024-06-11 — — US disclosed
CN-113631538-B Novel potassium channel inhibitors 萨尼奥纳有限责任公司 2024-05-31 — — CN disclosed
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2022-06-02 — — US disclosed
EP-3941903-A1 NOVEL POTASSIUM CHANNEL INHIBITORS Saniona A/S (DK) 2022-01-26 — — EP disclosed
CN-113631538-A Novel potassium channel inhibitors 萨尼奥纳有限责任公司 2021-11-09 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12391644-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 KCNN4 48/4885F2 4634/4885F9 4679/4885
US-20240368077-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 KCNN4 57/4885F2 4857/4885F9 4818/4885
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 KCNN4 57/4885F2 4857/4885F9 4818/4885
US-12006289-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 KCNN4 48/4885F2 4634/4885F9 4679/4885
US-20260049054-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SCN10A, KCNK10, KCNJ2 KCNN4 43/4885F2 1635/4885F9 296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.