Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742793 | 0.95 | HSD11B1 (0.48) | HSD11B1ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5572597 | 0.84 | LMNA (0.55) | ALDH1A1MEN1GAAKMT2ANPSR1 | |
| SCHEMBL4573204 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL349449 | 0.83 | AKR1C1 (0.52) | HSD11B1ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL38658664 | 0.76 | ALDH1A1 (0.44) | HSD11B1ALDH1A1NPC1MAPTKDM4E | |
| SCHEMBL349915 | 0.75 | MAPT (0.46) | HSD11B1ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL20491201 | 0.74 | NPSR1 (0.50) | HSD11B1ALDH1A1RAB9AMAPTALOX15 | |
| SCHEMBL4767629 | 0.73 | NPC1 (0.61) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL1397421 | 0.73 | NPC1 (0.61) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL4873981 | 0.73 | NPC1 (0.61) | ALDH1A1NPC1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020192302-A1 | PYRIMIDINE-CONTAINING TRI-SUBSTITUTED IMIDAZOLE COMPOUND AND APPLICATION THEREOF | 广州必贝特医药技术有限公司 | 2020-10-01 | — | — | WO | disclosed |